Key result
Among 75 patients with pulmonary infarction due to acute pulmonary embolism, the reversed halo sign was observed in 38.4% of lesions (33 of 86), predominantly in a subpleural location.
Why the study?
The study was conducted to determine the incidence of the reversed halo sign in patients with pulmonary infarction due to acute pulmonary embolism detected by computed tomography angiography, and to describe its morphological features.
Observational (n=993)
The reversed halo sign is a frequent morphological feature in pulmonary infarction due to acute pulmonary embolism on CTA, typically presenting as a subpleural oval lesion.
RHS on CTA in PI warrants PE consideration in differentials; leaves open prospective validation of diagnostic specificity.
OBJECTIVE: To determine the incidence of the reversed halo sign (RHS) in patients with pulmonary infarction (PI) due to acute pulmonary embolism (PE), detected by computed tomography angiography (CTA) of the pulmonary arteries, and to describe the main morphological features of the RHS. METHODS: We evaluated 993 CTA scans, stratified by the risk of PE, performed between January of 2010 and December of 2014. Although PE was detected in 164 scans (16.5%), three of those scans were excluded because of respiratory motion artifacts. Of the remaining 161 scans, 75 (46.6%) showed lesions consistent with PI, totaling 86 lesions. Among those lesions, the RHS was seen in 33 (38.4%, in 29 patients). RESULTS: Among the 29 patients with scans showing lesions characteristic of PI with the RHS, 25 (86.2%) had a single lesion and 4 (13.8%) had two, totaling 33 lesions. In all cases, the RHS was in a subpleural location. To standardize the analysis, all images were interpreted in the axial plane. Among those 33 lesions, the RHS was in the right lower lobe in 17 (51.5%), in the left lower lobe in 10 (30.3%), in the lingula in 5 (15.2%), and in the right upper lobe in 1 (3.0%). Among those same 33 lesions, areas of low attenuation were seen in 29 (87.9%). The RHS was oval in 24 (72.7%) of the cases and round in 9 (27.3%). Pleural effusion was seen in 21 (72.4%) of the 29 patients with PI and the RHS. CONCLUSIONS: A diagnosis of PE should be considered when there are findings such as those described here, even in patients with nonspecific clinical symptoms.
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Mançano et al. (2019) conducted an observational in Acute pulmonary embolism and pulmonary infarction (n=993). Acute pulmonary embolism with pulmonary infarction was evaluated on Incidence of the reversed halo sign in pulmonary infarction lesions. Among 75 patients with pulmonary infarction due to acute pulmonary embolism, the reversed halo sign was observed in 38.4% of lesions (33 of 86), predominantly in a subpleural location.
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