Key result
Fetal aortic valvuloplasty in fetuses with evolving hypoplastic left heart syndrome was associated with 44% postnatal survival, compared to a 2.6% survival rate in the HLHS cohort.
Why the study?
Data were lacking describing the survival of fetuses or neonates with AoS or HLHS in a country with suboptimal postnatal management.
Does fetal aortic valvuloplasty improve survival in fetuses with evolving hypoplastic left heart syndrome in a country with suboptimal postnatal management?
Comparison
Fetal aortic valvuloplasty for evolving HLHS vs standard postnatal management
Design
Prospective cohort study
Authors
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HLHS survival <5% in Mexico; leaves open whether fetal valvuloplasty improves biventricular outcomes in similar low-resource settings.
Cohort (n=54)
Does fetal aortic valvuloplasty improve survival in fetuses with evolving hypoplastic left heart syndrome in a country with suboptimal postnatal management?
Absolute Event Rate: 44% vs 2.6%
In a setting with suboptimal postnatal management, fetal aortic valvuloplasty for evolving HLHS is associated with approximately 44% survival, whereas established HLHS carries a >95% mortality rate.
Cruz‐Lemini et al. (2019) conducted a cohort in Aortic stenosis and hypoplastic left heart syndrome (n=54). Fetal aortic valvuloplasty vs. No fetal intervention (HLHS cohort) was evaluated on Overall postnatal survival. Fetal aortic valvuloplasty in fetuses with evolving hypoplastic left heart syndrome was associated with 44% postnatal survival, compared to a 2.6% survival rate in the HLHS cohort.
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