Key result
Analysis of recent literature indicates that the proposed role of maxi-K+ channels in the respiratory burst is not credibly established, and H+ efflux remains the most viable mechanism.
Population
Phagocytes (basic science model)
Design
Review
Authors
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H+ efflux via proton channels should remain the primary focus in phagocyte studies; leaves open maxi-K+ involvement pending direct validation.
Analysis of recent data suggests that H+ efflux through proton channels remains the most viable mechanism for charge compensation during the respiratory burst in phagocytes, challenging recent proposals favoring maxi-K+ channels.
Thomas E. DeCoursey (2004) conducted a review in Respiratory burst in phagocytes. Proton channels vs Potassium channels was evaluated. Analysis of recent literature indicates that the proposed role of maxi-K+ channels in the respiratory burst is not credibly established, and H+ efflux remains the most viable mechanism.
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