Key result
PMA stimulation of human eosinophils activated larger and more transient proton and electron currents compared to neutrophils, modulating H+ channel properties during the respiratory burst.
Population
Human eosinophils and neutrophils
Comparison
Phorbol myristate acetate stimulation and ZnCl2… vs Unstimulated cells (baseline)
Design
Preclinical
Authors
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Caution against extrapolating neutrophil findings to eosinophils; hypothesis-generating for H+ channel roles, requiring in vivo validation.
PMA activates H+ efflux during the respiratory burst in human eosinophils by modulating H+ channel properties, with larger and more transient currents compared to neutrophils.
DeCoursey et al. (2001) studied this question. Phorbol myristate acetate (PMA) vs. Unstimulated cells / neutrophils was evaluated on Proton and electron currents and superoxide anion release. PMA stimulation of human eosinophils activated larger and more transient proton and electron currents compared to neutrophils, modulating H+ channel properties during the respiratory burst.
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