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Collagenases derived from bovine and human gingiva are inhibited effectively by serum. In bovine and human serum fractionated by gel chromatography, alpha2-macroglobulin is the only significant inhibitor of gingival collagenase. alpha11-Antitrypsin inhibited collagenase only in very high concentration and was several hundred-fold less effective than alpha2-macroglobulin. Inhibition of gingival collagenase with alpha2-macroglobulin is accompanied by the formation of an enzyme-inhibitor complex, which has retained no collagenolytic activity.
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Birkedal‐Hansen et al. (1974) studied this question.
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