Key result
In 2021, the global age-standardized incidence rate of elderly myocarditis was 47.57 per 100,000 (95% CI 27.52-73.08), with a recent upward trend driven by population growth and aging.
Why the study?
Geriatric myocarditis represents a significant public health concern that potentially leads to various cardiac diseases, prompting the quantification of its burden over three decades and forecasting of future trends.
Observational
Yes
The global incidence of elderly myocarditis has shown a recent upward trend, and driven by population growth and aging, the number of cases is projected to exceed 1 million by 2045.
Answers are grounded in this paper and cite their sources.
Rising elderly myocarditis incidence amid aging populations may increase clinical burden; leaves open targeted surveillance and prevention research.
OBJECTIVE: Geriatric myocarditis represents a significant public health concern, directly influencing overall health and potentially leading to various cardiac diseases. This study seeks to quantify the burden of geriatric myocarditis over three decades (1992-2021) and provide forecasts for future disease burden. METHODS: Data on geriatric myocarditis from 1992 to 2021 was obtained from the Global Burden of Disease study, offering insights into the incidence of the condition, categorized by gender. The Joinpoint regression model was utilized to identify shifts in epidemiological trends, while decomposition analysis helped identify the underlying factors contributing to these trends. To project future incidence, deaths and DALYs (Disability-Adjusted Life Years), the Norpred and Bayesian Age-Period-Cohort (BAPC) models were employed. RESULTS: In 2021, the global ASIR (per 100,000) of elderly myocarditis was 47.57 (27.52-73.08), with 505,147 (292,319-774,561) cases. Age-standardized deaths(per 100,000) were 2.07 (1.55-2.51), totaling 20,718 (15,525-25,085) deaths, and age-standardized DALYs(per 100,000) were 29.77 (22.60-35.81), with 308,101 (234,226-370,674) DALYs. Greenland, Canada, and Austria had the highest ASIR(per 100,000), while Romania, Kazakhstan, and Croatia had the highest age-standardized deaths(per 100,000), and Romania, Kazakhstan, and Guyana had the highest age-standardized DALYs(per 100,000). Joinpoint Regression analysis revealed a recent upward trend in global incidence after a previous decline, consistent across genders and SDI regions. Deaths and DALYs showed declining trends globally, though male deaths recently increased. Decomposition analysis identified population growth and aging as key drivers of increased cases, deaths, and DALYs. Based on the nordpred model, by 2045, the global ASIR(per 100,000) is predicted to be 47.27, with 1,005,593 cases, age-standardized deaths(per 100,000) of 2.02, totaling 48,501 deaths, and age-standardized DALYs(per 100,000) of 26.21, with 595,694 DALYs. The BAPC model predicts a global ASIR(per 100,000) of 51.82, with 1,091,195 cases, age-standardized deaths(per 100,000) of 3.67, totaling 87,145 deaths, and age-standardized DALYs(per 100,000) of 49.09, with 1,084,738 DALYs. CONCLUSION: As of 2021, the ASIR(per 100,000) of myocarditis in the elderly population showed a decline compared to 1992; however, a recent upward trend has been identified. Considering ongoing population growth, the number of myocarditis cases among the elderly is anticipated to increase.
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Wang et al. (2025) conducted an observational in Geriatric myocarditis. Time period (1992-2021) vs. 1992 was evaluated on Age-standardized incidence rate (ASIR) per 100,000 in 2021 (95% CI 27.52-73.08). In 2021, the global age-standardized incidence rate of elderly myocarditis was 47.57 per 100,000 (95% CI 27.52-73.08), with a recent upward trend driven by population growth and aging.
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