In vitro study reveals novel dihydroagarofuran sesquiterpenoids with selective anti-HIV activity from Maytenus spinosa leaves, highlighting their potential as therapeutic lead compounds.
Nine new β-dihydroagarofurans (1-9) and four new sesquiterpene pyridine alkaloids (10-13) were isolated from the leaves of Maytenus spinosa. Their structures were determined mainly by 1D- and 2D-NMR spectroscopic studies. The absolute configuration of compound 6 was established using CD spectroscopy. Several derivatives (14-20) were prepared from the sesquiterpene 13. Most of the sesquiterpenoids were tested for anti-HIV activity, but only compound 1 was found to be active.
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Gutiérrez-Nicolás et al. (2014) studied this question.
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