Key result
Higher TIMI risk scores in patients with acute coronary syndrome were significantly associated with severe coronary artery disease, with 54.1% of high-risk patients having three-vessel disease compared to 7.5% of low-risk patients.
Why the study?
ACS requires prompt treatment, and this study aimed to determine the association of TIMI score in predicting the severity of coronary artery disease in ACS patients.
Does the TIMI score correlate with the severity of coronary artery disease in patients with acute coronary syndrome?
Cross-Sectional (n=255)
No
Does the TIMI score correlate with the severity of coronary artery disease in patients with acute coronary syndrome?
Absolute Event Rate: 54.1% vs 7.5%
p-value: p=<0.001
Higher TIMI scores in patients with acute coronary syndrome significantly correlate with more severe angiographic coronary artery disease, including three-vessel and left main disease.
TIMI score was associated with CAD severity in ACS; leaves open whether it refines triage beyond angiography in practice.
Background: ACS presents as wide range of clinical ailments that requires prompt treatment to avoid unforeseen circumstances. As noninvasive strategy, TIMI risk assessment is a widely accepted tool for risk stratification of ACS patient to initiate timely management. Purpose of the present study is to determine the association of TIMI score in predicting the severity of coronary artery disease in ACS. Methodology: A cross-sectional study was conducted in specialized tertiary care cardiac hospital on 255 patients from January 2021 to June 2021. For all patients, TIMI score calculated based on all the seven variables. Confidentiality of the participants was maintained. Ethical approval was obtained from review board of concerned hospital. Data was analyzed on SPSS version 23.0. One way ANOVA was used to compare categorical variables. Chi square test used to reveal difference in proportion to three TIMI groups. Results: Finding show that ST segment deviation was evident in 51.5% patients. Out of 37 patients in group-III with ST segment changes, 91.8% were found of having significant CAD. Results show that in group-III, 54.1% had significant three vessel CAD compared to 17.6% group-II & 7.5% group-I patients. Also, p-value of <0.001 depict significant association between TIMI score and severity of CAD. Conclusion: A significant association from this study gives a notion that TIMI score is valuable tool in clinical setting to make urgent decision regarding the management of CAD. Also, it was concluded from current study that patients with higher TIMI score had additional risk of three vessel CAD and left main vessel CAD in patients with ACS.
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Hasan et al. (2022) conducted a cross-sectional in Acute coronary syndrome (n=255). TIMI risk score vs. Low TIMI risk score was evaluated on Significant three-vessel coronary artery disease (p=<0.001). Higher TIMI risk scores in patients with acute coronary syndrome were significantly associated with severe coronary artery disease, with 54.1% of high-risk patients having three-vessel disease compared to 7.5% of low-risk patients.
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