Key result
Eight different hybridoma cell lines producing monoclonal antibodies against major antigens of human adenovirus type 5 were obtained and characterized, revealing diverse hexon specificities.
The study successfully generated and characterized eight hybridoma cell lines producing monoclonal antibodies against human adenovirus type 5, revealing multiple subgroup specificities in the hexon antigen.
May aid adenovirus research tools; leaves open clinical diagnostic or therapeutic translation pending human validation.
Eight different hybridoma cells lines producing monoclonal antibodies against the major antigens of human adenovirus type 5 have been obtained. They were selected by screening initial hybridomas by the fluorescent antibody technique followed by radioimmune precipitation and they reacted with hexon, penton, fibre and 100K polypeptides. Five apparently different epitopes against the hexon antigen were detected showing a spectrum of activity against the hexons of other serotypes, suggesting that the hexon contained a variety of subgroup specificities as well as the previously described group and type specificities.
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Russell et al. (1981) studied Human adenovirus type 5. Monoclonal antibodies against human adenovirus type 5 was evaluated on Production and characterization of hybridoma cell lines. Eight different hybridoma cell lines producing monoclonal antibodies against major antigens of human adenovirus type 5 were obtained and characterized, revealing diverse hexon specificities.
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