Key result
Undetected mutations challenge serum alpha-1 antitrypsin threshold validity in the AVATAR cohort.
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Challenges AAT threshold validity in AVATAR; leaves open mutation-adjusted associations pending reanalysis.
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Jalota et al. (2026) studied this question. Methodological considerations regarding serum alpha-1 antitrypsin threshold analysis in the AVATAR cohort were raised concerning undetected mutations.
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