What question did this study set out to answer?

To evaluate potential mechanistic defects underlying impaired graft function and insulin secretion following intraportal islet transplantation in patients with type 1 diabetes.

January 1, 2005DiabetesOpen Access

β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes

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Authors

MRMichael R. RickelsBryn Mawr College MSMark H. SchuttaChildren's Hospital of Philadelphia JMJames F. MarkmannUniversity of Pennsylvania

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Implication

Observational study reveals impaired beta-cell secretory capacity after intraportal islet transplantation in type 1 diabetes, indicating insufficient engrafted functional islet mass.

Key Points

To evaluate potential mechanistic defects underlying impaired graft function and insulin secretion following intraportal islet transplantation in patients with type 1 diabetes.
Assessed recipients after intraportal islet transplantation at 3 months (n = 5) and 12 months (n = 4) who received comparable islet equivalents per kilogram (12,601 ± 1,732 vs. 14,384 ± 2,379).
Measured C-peptide responses following intravenous glucose (0.3 g/kg), a 600-kcal oral meal, and intravenous arginine (5 g), and conducted glucose-potentiated arginine tests in insulin-independent recipients (n = 5).
C-peptide responses were significantly decreased in both the 3-month and 12-month post-transplant cohorts compared to healthy controls across all stimuli (P < 0.05), with the greatest defect observed during intravenous glucose testing and worse impairment at 12 months.
Insulin-independent recipients exhibited significant reductions in the glucose-potentiation slope (P < 0.05) and maximal secretory capacity to arginine (ARmax; P < 0.05).

Cite This Study

Rickels et al. (2005) studied this question.

synapsesocial.com/papers/6a9ba32cf2c777f0ee5a8e52 https://doi.org/10.2337/diabetes.54.1.100

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Implication

Observational study reveals impaired beta-cell secretory capacity after intraportal islet transplantation in type 1 diabetes, indicating insufficient engrafted functional islet mass.

β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

β-Cell Function Following Human Islet Transplantation for Type 1 Diabetes

Discussion

Member takes

Implication

Key Points

Cite This Study

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