A new type of spider toxin with histamine-releasing activity was purified from the venom of the Joro spider, Nephila clavata, using high performance liquid chromatography. Three kinds of toxins (Nephilatoxins-7, -8 and -9) were isolated. They all possess the aromatic indole-3-acetyl group connected to N-termini of the hydrophilic and polycationic part constructed of basic amino acids and polyamines. The structural relation to the other spider toxins is discussed.
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Toki et al. (1988) studied this question.
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