Key result
A novel intracellular chloride channel, CLIC3, was identified and shown to form a stable complex with the carboxyl-terminal tail of ERK7, suggesting a role in regulating cell growth.
Identifies CLIC3 as a novel intracellular chloride channel that interacts with ERK7, suggesting a potential role in the regulation of cell growth.
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Hypothesis-generating for CLIC3 in growth regulation; leaves open any clinical translation pending human studies.
Qian et al. (1999) studied this question. CLIC3 and ERK7 interaction was evaluated on Identification and characterization of CLIC3. A novel intracellular chloride channel, CLIC3, was identified and shown to form a stable complex with the carboxyl-terminal tail of ERK7, suggesting a role in regulating cell growth.
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