Key result
The high sensitivity cardiac troponin T assay enables earlier diagnosis of myocardial infarction and improved risk prediction, but increases the detection of elevated troponin in non-ischemic conditions.
High sensitivity cardiac troponin T assays improve the detection of myocardial infarction but also identify elevated troponins in nonischemic conditions, necessitating careful clinical interpretation.
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Supports cautious hs-cTnT interpretation to avoid overdiagnosis; leaves open refinement of assay-specific thresholds in non-ACS cohorts.
Diagnostic and Prognostic Information Provided by a High Sensitivity Assay for Cardiac Troponin T Cardiac troponins (cTns) are the preferred biomarkers for the diagnosis of acute myocardial infarction, assessment of risk and prognosis, and for determination of antithrombotic and revascularization strategy in patients with acute coronary syndromes. The implementation of high sensitivity cTn assays into the clinical routine has increased the number of patients diagnosed with myocardial infarction. In addition, the number of patients with elevated cTn levels that cannot be explained by acute ischemic injury was increased, which is observed in patients with chronic heart disease and other nonischemic cardiac injury or in patients with impaired renal function. The new definition of myocardial infarction provides support for the interpretation of elevated cTn measured with high sensitivity cTn assays in patients with suspected acute coronary syndrome. This review will summarize clinical studies with the recently introduced high sensitivity cTnT assay (TnT hs) with reference to recent experience with high sensitivity cTn assays in general.
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Jochen Jarausch (2010) conducted a review in Acute myocardial infarction and other cardiac conditions. High sensitivity cardiac troponin T assay (TnT hs) vs. Conventional cardiac troponin assays was evaluated. The high sensitivity cardiac troponin T assay enables earlier diagnosis of myocardial infarction and improved risk prediction, but increases the detection of elevated troponin in non-ischemic conditions.
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