Key result
New oral anticoagulants, including dabigatran, rivaroxaban, apixaban, and edoxaban, are discussed as alternatives to vitamin K antagonists for stroke prevention in nonvalvular atrial fibrillation.
Why the study?
Do new oral anticoagulants provide a safe and effective alternative to vitamin K antagonists for stroke prevention in patients with nonvalvular atrial fibrillation?
Do new oral anticoagulants provide a safe and effective alternative to vitamin K antagonists for stroke prevention in patients with nonvalvular atrial fibrillation?
New oral anticoagulants are discussed as alternatives to vitamin K antagonists for stroke prevention in nonvalvular atrial fibrillation, aiming to overcome the disadvantages of warfarin such as regular blood testing and variable dose-effect relationships.
Patients with nonvalvular atrial fibrillation (AF) and risk factors for stroke need anticoagulation to avoid thromboembolic complications. Vitamin K antagonists (VKAs) are an established pharmacological group the use of which is recommended by guidelines. However, VKAs (like warfarin) have major disadvantages, such as a variable dose-effect relationship, drug and food interactions, the need for regular blood testing and dose titration, and, finally, a substantial risk of bleeding. New oral anticoagulants are intended to replace warfarin, being at least as safe and effective, and lacking some of the disadvantages of VKAs. Clinical data for dabigatran, rivaroxaban, apixaban and edoxaban, and other new drugs, are discussed in this article with special focus on their use in nonvalvular AF.
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Kozłowski et al. (2013) conducted a review in nonvalvular atrial fibrillation. New oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban) vs. Vitamin K antagonists was evaluated. New oral anticoagulants, including dabigatran, rivaroxaban, apixaban, and edoxaban, are discussed as alternatives to vitamin K antagonists for stroke prevention in nonvalvular atrial fibrillation.
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