Key result
Mitochondrial haplogroup H was significantly overrepresented in patients with ischemic cardiomyopathy compared to healthy controls (50.0% vs 40.0%, OR 1.50), acting as a risk factor.
Why the study?
Are mitochondrial DNA haplogroups H and J associated with the risk of developing ischemic cardiomyopathy?
Case-Control (n=781)
Yes
Are mitochondrial DNA haplogroups H and J associated with the risk of developing ischemic cardiomyopathy?
Mitochondrial DNA haplogroup H is associated with an increased risk of ischemic cardiomyopathy, whereas haplogroup J appears to be a protective factor.
Supports haplogroup H as potential ischemic cardiomyopathy risk marker; leaves open clinical utility pending prospective validation.
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Fernández-Caggiano et al. (2012) conducted a case-control in Ischemic Cardiomyopathy (n=781). Mitochondrial haplogroup H vs. Other mitochondrial haplogroups was evaluated on Prevalence of mitochondrial haplogroup H (OR 1.50, 95% CI 1.13-2.00, p=0.039). Mitochondrial haplogroup H was significantly overrepresented in patients with ischemic cardiomyopathy compared to healthy controls (50.0% vs 40.0%, OR 1.50), acting as a risk factor.
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