Key result
Severe periodontitis in young adults was associated with higher mean carotid intima-media thickness (0.82 vs 0.72 mm; P<0.0001) and increased odds of IMT ≥0.82 mm (OR 8.55; 95% CI 2.38-39.81).
Why the study?
Does severe periodontitis increase carotid intima-media thickness in young systemically healthy individuals?
Case-Control (n=90)
Does severe periodontitis increase carotid intima-media thickness in young systemically healthy individuals?
Odds Ratio: 8.55 (95% CI 2.38–39.81)
Absolute Event Rate: 0.82% vs 0.72%
p-value: p=<0.0001
Severe periodontitis is associated with increased sub-clinical atherosclerosis, as measured by carotid intima-media thickness, in young, systemically healthy adults.
AIM: The aim of this study was to evaluate the association between severe periodontitis and sub-clinical atherosclerosis in young (< or =40 years) systemically healthy individuals. MATERIAL AND METHODS: Ninety systemically healthy subjects, 45 affected by severe periodontitis (mean age 36.35+/-3.65 years) and 45 controls without a history of periodontal disease (mean age 33.78+/-3.28 years), were enrolled in this study. Patients and controls were paired for age, gender, body mass index and smoking habits. Carotid intima-media thickness (IMT) was bilaterally assessed by ultrasonography at the level of common carotid artery. Traditional cardiovascular risk factors for atherosclerosis were also evaluated. RESULTS: The overall mean carotid IMT was 0.82+/-0.13 mm in the test group and 0.72+/-0.07 mm in the control group ( p<0.0001). Stepwise regression analysis showed that periodontitis ( p<0.0001) and regular physical activity ( p=0.0009) were predictor variables of overall mean carotid IMT. When considering an IMT> or =0.82 mm as the critical index of increased cardiovascular risk, periodontal patients overcame this threshold compared with healthy patients by an odds ratio=8.55 [confidence interval 95%: 2.38; 39.81]. No investigated haemostatic variable was associated with increased carotid IMT. CONCLUSION: Severe periodontitis is associated with sub-clinical atherosclerosis in young systemically healthy patients.
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Cairo et al. (2008) conducted a case-control in Severe periodontitis (n=90). Severe periodontitis vs. Controls without a history of periodontal disease was evaluated on Overall mean carotid intima-media thickness (IMT) (OR 8.55, 95% CI 2.38-39.81, p=<0.0001). Severe periodontitis in young adults was associated with higher mean carotid intima-media thickness (0.82 vs 0.72 mm; P<0.0001) and increased odds of IMT ≥0.82 mm (OR 8.55; 95% CI 2.38-39.81).
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