Key result
PIP2 exerts a gain-of-function effect on maximal current amplitude and a loss-of-function effect by positive-shifting the activation voltage dependence in Shaker K+ channels.
Population
COS-7 cells and Xenopus oocytes heterologously expressing the voltage-dependent Shaker channel
Design
Preclinical
Authors
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Dual PIP2 effects on Shaker K+ channels merit exploration in mammalian models; leaves open relevance to cardiac arrhythmias.
PIP2 has a dual regulatory effect on Shaker K+ channels, stabilizing the open state while simultaneously shifting activation voltage dependence positively.
Abderemane-Ali et al. (2012) studied this question. Phosphatidylinositol (4,5)-bisphosphate (PIP2) was evaluated on Maximal current amplitude and activation voltage dependence. PIP2 exerts a gain-of-function effect on maximal current amplitude and a loss-of-function effect by positive-shifting the activation voltage dependence in Shaker K+ channels.
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