Key result
Magnetocardiography in 95 cynomolgus monkeys established normal parameters (e.g., mean QTc 363+/-25), with no significant differences between females and males.
Observational (n=95)
This study establishes normal magnetocardiogram parameter values for cynomolgus monkeys, facilitating future preclinical electrophysiological research.
To establish the electrophysiological mappings of nonhuman primates by using magnetocardiogram (MCG) data and obtain the normal values of MCG parameters, we used 64-channel superconducting quantum interference devices to measure 8x8 MCG data for 95 cynomolgus monkeys (Macaca fascicularis, 51 female and 44 male). The PQ interval, QRS duration, QT interval and QTc were respectively 79+/-14 ms, 42+/-7 ms, 222+/-23 ms and 363+/-25 (mean+/-SD), and these parameters did not differ significantly between female and male monkeys. These results indicate the normal values of the MCG parameters of the cynomolgus monkey and should facilitate animal experiments in magnetocardiography.
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Seki et al. (2008) conducted an observational in Healthy nonhuman primates (n=95). Magnetocardiogram (MCG) was evaluated on Normal values of MCG parameters (PQ interval, QRS duration, QT interval, QTc). Magnetocardiography in 95 cynomolgus monkeys established normal parameters (e.g., mean QTc 363+/-25), with no significant differences between females and males.
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