Key result
A newly developed micro-magnetocardiography system successfully recorded PQRST complexes, detected regional myocardial injury patterns, and identified quinidine-induced QT prolongation in small animals.
A novel micro-magnetocardiography system enables noncontact, accurate electrophysiological assessment and QT analysis in small animals, offering a potential tool for high-throughput drug screening.
Feasibility demonstrated in small animals; leaves open validation for drug screening or human translation.
Development of drugs requires electrophysiological studies of small animals like mice, rats or guinea pigs. Electrocardiography (ECG) of hirsute animals is time-consuming. We have developed a micro magnetometer array with a 9-channel superconducting quantum interference device (SQUID) with a 2.5-mm diameter pickup-coil for noncontacting measurement of magnetocardiograms (MCGs) in small animals. The micro-MCG successfully recorded the PQRST complex in mice, rats and guinea pigs. A regional myocardial injury was made in rat hearts with a cryoinjury probe, and the characteristic pattern of the injury was recorded in the MCG. An anterior myocardial injury created a QS pattern in the MCG, and a posterior myocardial injury created a QR pattern in the MCG. Quinidine-induced QT prolongation was successfully detected by micro-MCG in mice and rats. Simultaneous recording of ECG and MCG was conducted after intraperitoneal administration of quinidine (60 mg/kg) in guinea pigs. QT interval corrected for heart rate (QTc) in both ECG and MCG correlated well. The newly developed micro-MCG may facilitate electrophysiological studies of small animals, and may enable high-throughput screening of drug-induced QT abnormality.
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Komamura et al. (2008) studied Myocardial injury and QT prolongation in small animals. Micro-magnetocardiography (micro-MCG) system vs. Electrocardiography (ECG) was evaluated on Detection of PQRST complex, myocardial injury patterns, and QT prolongation. A newly developed micro-magnetocardiography system successfully recorded PQRST complexes, detected regional myocardial injury patterns, and identified quinidine-induced QT prolongation in small animals.
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