What is the clinical evidence from this study?

Study design: Case Report. Population: Auricular fibrillation and flutter (n=1). Intervention: Quinidin sulphate. Primary outcome: Respiratory paralysis.

What question did this study set out to answer?

Document an uncommon case of respiratory paralysis during quinidin therapy and review similar adverse reactions.

December 9, 1922JAMA

Respiratory Paralysis Following Quinidin Therapy

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Key result

Quinidin sulphate therapy for auricular fibrillation and flutter was associated with a rare case of respiratory paralysis.

Why the study?

Does quinidine sulphate cause respiratory paralysis in patients with auricular fibrillation and flutter?

Population

Patients with auricular fibrillation and flutter

Design

Case_report

Authors

WRWILLIAM D. REIDNewcastle University

Discussion

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Implication

May signal rare respiratory paralysis with quinidine for atrial arrhythmias; single case report leaves open incidence and causality.

Key Points

Document an uncommon case of respiratory paralysis during quinidin therapy and review similar adverse reactions.
Clinical observation and toxicity assessment of an inpatient treated with quinidin sulphate for cardiac arrhythmia at Boston City Hospital.
Review of historical case reports detailing fatal complications and neuro-respiratory failures following quinidin administration.
A single instance of complete respiratory paralysis developed following quinidin sulphate therapy.
Fatalities from quinidin therapy typically result from embolism or cardiac standstill linked to heart block, making primary respiratory arrest an exceptionally rare outcome.

Study Design

Type

Case Report (n=1)

Multicenter

Structured PICO

Does quinidine sulphate cause respiratory paralysis in patients with auricular fibrillation and flutter?

Population

A single case report of a patient treated with quinidin sulphate for auricular fibrillation or flutter who developed respiratory paralysis.

Intervention

Quinidine sulphate

Outcome

Respiratory paralysissafety

Highlights a rare but severe adverse effect (respiratory paralysis) associated with quinidine therapy for atrial arrhythmias.

Cite This Study

WILLIAM D. REID (1922) conducted a case report in Auricular fibrillation and flutter (n=1). Quinidin sulphate was evaluated on Respiratory paralysis. Quinidin sulphate therapy for auricular fibrillation and flutter was associated with a rare case of respiratory paralysis.

synapsesocial.com/papers/6a9bb92f9e35130f9d41d3c5 https://doi.org/10.1001/jama.1922.02640240008003

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Respiratory Paralysis Following Quinidin Therapy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Respiratory Paralysis Following Quinidin Therapy

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

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