One monozygotic twin is afflicted with arthrogryposis multiplex congenita. A review of the literature has revealed an apparently inconsistent pattern of transmission, conflicting views as to the primary site of involvement, a wide spectrum of variably associated congenital anomalies, and a postulated link with other identified neurologic disorders. We support the proposal that arthrogryposis is a sign present in several syndromes, probably of differing etiologies. Classification under this purely descriptive term should be avoided.
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Frank A. Pedreira (1971) studied this question.
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