Key result
Black patients with STEMI had higher rates of in-hospital major bleeding than white patients when treated with fibrinolysis (10.9% vs 10.3%; OR 1.21) or primary PCI (10.3% vs 7.8%; OR 1.33).
Why the study?
Does Black race increase the risk of in-hospital major bleeding and mortality compared to White race in patients with STEMI receiving reperfusion therapy?
Cohort (n=93,684)
Yes
Does Black race increase the risk of in-hospital major bleeding and mortality compared to White race in patients with STEMI receiving reperfusion therapy?
Odds Ratio: 1.21 (95% CI 1.02–1.43)
Absolute Event Rate: 10.9% vs 10.3%
Black patients with STEMI undergoing reperfusion therapy face a significantly higher risk of in-hospital major bleeding compared to White patients, though in-hospital mortality remains similar.
Supports heightened bleeding vigilance in Black STEMI patients; extends disparity observations while leaving targeted mitigation untested.
BACKGROUND: Prior studies have suggested that blacks with acute ST-segment-elevation myocardial infarction have increased bleeding risks with fibrinolysis relative to whites, yet these data were quite limited. Additionally, it is unknown whether there are racial differences in bleeding risks among patients with ST-segment-elevation myocardial infarction receiving primary percutaneous coronary intervention. METHODS AND RESULTS: We evaluated data on blacks and whites with ST-segment-elevation myocardial infarction treated with either fibrinolysis or primary percutaneous coronary intervention from the National Registry of Myocardial Infarction (NRMI)-4 and 5 participating centers between July 2000 and December 2006. We compared differences between the 2 groups in rates of in-hospital major bleeding and mortality, adjusted with logistic regression analyses. In fibrinolytic-treated patients with ST-segment-elevation myocardial infarction, the bleeding rates were higher among blacks (n=2283) than whites (n=42 243; 10.9% versus 10.3%; adjusted odds ratio, 1.21; 95% confidence interval, 1.02-1.43). Similarly, in patients receiving primary percutaneous coronary intervention, the bleeding rates were higher in blacks (n=2826) than in whites (n=46 332; 10.3% versus 7.8%; adjusted odds ratio, 1.33; 95% confidence interval, 1.13-1.56). Bleeding was associated with higher risk of death in both ethnic groups. However, there was no overall racial difference in in-hospital mortality among those with bleeding or without bleeding treated with either fibrinolysis or primary percutaneous coronary intervention. CONCLUSIONS: Blacks with ST-segment-elevation myocardial infarction treated with either fibrinolysis or primary percutaneous coronary intervention had a higher risk of bleeding events than their white counterparts. Bleeding was associated with a similar increased risk of death in both ethnic groups treated by either reperfusion strategy.
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Mehta et al. (2012) conducted a cohort in ST-segment-elevation myocardial infarction (n=93,684). Black race vs. White race was evaluated on in-hospital major bleeding (OR 1.21, 95% CI 1.02-1.43). Black patients with STEMI had higher rates of in-hospital major bleeding than white patients when treated with fibrinolysis (10.9% vs 10.3%; OR 1.21) or primary PCI (10.3% vs 7.8%; OR 1.33).
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