Key result
G-CSF significantly improved left ventricular ejection fraction and reduced scar area at 28 days post-MI, effects that were inhibited by the CXCR4 inhibitor AMD3100.
Why the study?
Does G-CSF improve cardiac repair via recruitment of CXCR4+ cells in a rabbit model of myocardial infarction?
Does G-CSF improve cardiac repair via recruitment of CXCR4+ cells in a rabbit model of myocardial infarction?
The beneficial effects of G-CSF on post-infarct cardiac repair are primarily mediated by the recruitment of bone marrow-derived CXCR4+ cells via the CXCR4/SDF-1 axis.
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Supports G-CSF effects via CXCR4+ recruitment in rabbit MI; hypothesis-generating and should not inform clinical practice.
Misao et al. (2006) studied Myocardial infarction (n=80). G-CSF vs. Saline was evaluated on Left ventricular ejection fraction, end-diastolic dimensions, and scar area/left ventricular wall area ratio. G-CSF significantly improved left ventricular ejection fraction and reduced scar area at 28 days post-MI, effects that were inhibited by the CXCR4 inhibitor AMD3100.
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