Key result
A low dose but long duration of G-CSF treatment significantly increased myocardial percentage uptake of Thallium-201 in angina patients and improved the ejection fraction curve in AMI patients without serious complications.
Why the study?
Does low-dose, long-duration G-CSF improve myocardial perfusion and left ventricular function in patients with coronary heart disease?
RCT (n=46)
Open-label
Randomly assigned
Yes
Does low-dose, long-duration G-CSF improve myocardial perfusion and left ventricular function in patients with coronary heart disease?
p-value: p=<0.05
Low-dose, long-duration G-CSF therapy appears safe and may improve myocardial perfusion in intractable angina and left ventricular function in acute myocardial infarction.
No takes yet. Share an insight, caveat, or question.
May support adjunctive G-CSF in refractory angina and post-MI LV recovery; extends cytokine mobilization data to low-dose regimens.
Suzuki et al. (2006) conducted an RCT in Coronary Heart Disease (Angina or Acute Myocardial Infarction) (n=46). Granulocyte colony-stimulating factor (G-CSF) / lenograstim vs. Non-G-CSF control (conventional therapy) was evaluated on Percentage uptake on stress images by Thallium-201 in the ischemic area at 1 month (Angina group) (p=<0.05). A low dose but long duration of G-CSF treatment significantly increased myocardial percentage uptake of Thallium-201 in angina patients and improved the ejection fraction curve in AMI patients without serious complications.
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