Key result
Pomegranate peel extract significantly reduced relative heart weight and ameliorated cardiac hypertrophy in diabetic rats compared to untreated diabetic controls.
Why the study?
Pyroptosis is closely linked to diabetic cardiomyopathy and pomegranate peel extract exhibits cardioprotective effects, but the underlying mechanisms of protection in diabetic cardiomyopathy remained to be investigated.
Does pomegranate peel extract protect against the development of diabetic cardiomyopathy in a rat model of Type 1 diabetes?
Population
Streptozotocin-induced type 1 diabetic rats
Comparison
Pomegranate peel extract (150 mg/kg orally daily) vs untreated controls
Design
Animal experimental study
Follow-up
8 weeks
Authors
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PPE may protect against diabetic cardiomyopathy in rats; hypothesis-generating and requires human studies before clinical consideration.
Does pomegranate peel extract protect against the development of diabetic cardiomyopathy in a rat model of Type 1 diabetes?
Absolute Event Rate: 0.391% vs 0.488%
p-value: p=<0.001
Pomegranate peel extract exhibits cardioprotective potential against diabetic cardiomyopathy in a rat model by inhibiting pyroptosis and downregulating lncRNA-MALAT1.
Abo-Saif et al. (2023) studied Diabetic cardiomyopathy (n=48). Pomegranate peel extract vs. Vehicle (0.1 M sodium citrate buffer) was evaluated on Relative heart weight (marker of cardiac hypertrophy) (p=<0.001). Pomegranate peel extract significantly reduced relative heart weight and ameliorated cardiac hypertrophy in diabetic rats compared to untreated diabetic controls.
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