Key result
Men had a significantly higher incidence of left ventricular reverse remodeling (50% vs 26%) compared to women 3 months after transcatheter aortic valve implantation.
Why the study?
Does transcatheter aortic valve implantation improve left ventricular reverse remodeling differently in men versus women with severe aortic stenosis?
Cohort (n=100)
No
Does transcatheter aortic valve implantation improve left ventricular reverse remodeling differently in men versus women with severe aortic stenosis?
Absolute Event Rate: 50% vs 26%
p-value: p=0.013
Men and women with severe aortic stenosis exhibit different patterns of left ventricular remodeling and reverse remodeling after TAVI, with men showing a higher incidence of reverse remodeling defined by volume reduction.
Sex differences in post-TAVI LV remodeling may inform risk stratification; hypothesis-generating and requires prospective validation before clinical adoption.
, P = 0.006) volumes. After TAVI, women (-6.0% ± 14.4%) had higher reduction in the rate of change of relative wall thickness (RWT) than did men (4.4% ± 19.0%, P = 0.003). Men (-8.9% ± 3.9%) had higher reduction in the rate of change of LVEDVi than did women (1.5% ± 3.3%, P = 0.045). Incidence of LV reverse remodeling defined as a reduction in LVESV of >15% was significantly higher in men (50%) than in women (26%, P = 0.013).In addition to sex differences in the pattern of LV remodeling with AS, reverse LV remodeling after TAVI also differed between sexes.
No takes yet. Share an insight, caveat, or question.
Ninomiya et al. (2020) conducted a cohort in Severe aortic stenosis (n=100). Male sex vs. Female sex was evaluated on Incidence of LV reverse remodeling (reduction in LVESV of >15%) (p=0.013). Men had a significantly higher incidence of left ventricular reverse remodeling (50% vs 26%) compared to women 3 months after transcatheter aortic valve implantation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: