Key result
Molecular imaging techniques such as PET, SPECT, MRI, and contrast-enhanced ultrasound offer promising noninvasive methods to monitor myocardial angiogenesis and evaluate regenerative therapies after myocardial infarction.
Noninvasive molecular imaging of angiogenesis provides a promising tool to monitor myocardial healing and evaluate the efficacy of regenerative therapies after myocardial infarction.
PURPOSE OF REVIEW: Myocardial infarction (MI) leading to heart failure displays an important cause of death worldwide. Adequate restoration of blood flow to prevent this transition is a crucial factor to improve long-term morbidity and mortality. Novel regenerative therapies have been thoroughly investigated within the past decades. RECENT FINDINGS: Increased angiogenesis in infarcted myocardium has shown beneficial effects on the prognosis of MI; therefore, the proangiogenic capacity of currently tested treatments is of specific interest. Molecular imaging to visualize formation of new blood vessels in vivo displays a promising option to monitor proangiogenic effects of regenerative substances. SUMMARY: Based on encouraging results in preclinical models, molecular angiogenesis imaging has recently been applied in a small set of patients. This article reviews recent literature on noninvasive in vivo molecular imaging of angiogenesis after MI as an integral part of cardiac regeneration.
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Mandic et al. (2016) conducted a review in Myocardial infarction. Molecular imaging of angiogenesis was evaluated. Molecular imaging techniques such as PET, SPECT, MRI, and contrast-enhanced ultrasound offer promising noninvasive methods to monitor myocardial angiogenesis and evaluate regenerative therapies after myocardial infarction.
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