Key result
ABO blood groups showed no significant relationship with coronary atherosclerotic markers and pericardial fat volume, although non-O blood groups correlated with CAC and PFV after adjustment.
Why the study?
Is there a relationship between ABO blood groups and coronary atherosclerotic markers or pericardial fat volume in patients with suspected coronary artery disease?
Cross-Sectional (n=180)
No
Is there a relationship between ABO blood groups and coronary atherosclerotic markers or pericardial fat volume in patients with suspected coronary artery disease?
p-value: p=>0.05
Non-O blood groups may be associated with increased coronary artery calcification, coronary plaque, and pericardial fat volume after adjusting for other factors in patients with suspected CAD.
Non-O blood group may associate with CAC, plaque, and PFV after adjustment in suspected CAD; leaves open whether ABO typing improves risk stratification.
Background: The mechanisms linking ABO blood group to coronary atherosclerosis is inconsistent and not fully understood.Objectives: To investigate the relationship between ABO blood groups with coronary atherosclerotic markers (coronary artery calcification (CAC), coronary plaque presence and coronary luminal stenosis (CAD)) and pericardial fat volume (PFV) in patients with suspected coronary artery disease assessed by Multidetector CT angiography (MDCT).Patients and methods: Two hundred twenty consecutive patients who underwent 64-slice MDCT angiography for assessment of coronary artery disease were recruited.Of these, 180 patients (97 females (54%) and 83 males (46%) with a mean age of 51.7 Æ 12 years) were found to be eligible and were enrolled in the study.Results: We classified the blood groups into O blood group (51.6%) and non O blood group (38%).There were no significant differences in the distribution of CAC, CAD, PFV and coronary plaque presence between different blood groups (P > 0.05).The distribution of major cardiovascular risk factors did not differ significantly among the ABO blood groups, except for a significant association between O blood group and smoking (P Z 0.04).Adjustment for age and sex showed no significant associations between blood groups with coronary atherosclerotic markers or PFV (P > 0.05).Non O blood group were significantly correlated with CAC (P Z 0.01), coronary plaque (P Z 0.04) and PFV (P Z 0.03) after adjustment for CAD and CAC.
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Nafakhi et al. (2016) conducted a cross-sectional in Suspected coronary artery disease (n=180). Non-O blood group vs. O blood group was evaluated on Coronary atherosclerotic markers (CAC, coronary plaque presence, CAD) and pericardial fat volume (p=>0.05). ABO blood groups showed no significant relationship with coronary atherosclerotic markers and pericardial fat volume, although non-O blood groups correlated with CAC and PFV after adjustment.
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