Key result
Compared with ideal categories, poor categories of blood pressure and fasting glucose were associated with the highest (approximately two-fold) increased risk for atherosclerotic cardiovascular disease events.
Why the study?
Data showed no substantial increase nationally in patients achieving ideal CVH metrics, prompting an evaluation of CVH metric distributions and their contribution to subsequent ASCVD risk in a large, contemporary population.
Does poor status in cardiovascular health metrics increase the risk of ASCVD events in adults without prior known ASCVD?
Population
991,698 adults without prior known ASCVD in Kaiser Permanente Northern California
Comparison
Poor or intermediate vs ideal status across six AHA CVH metrics
Design
Retrospective cohort study
Follow-up
During the calendar year 2015
Authors
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CVH metrics aid risk assessment in practice; leaves open need for post-2020 target validation in diverse cohorts.
Cohort (n=991,698)
Does poor status in cardiovascular health metrics increase the risk of ASCVD events in adults without prior known ASCVD?
Poor status in individual cardiovascular health metrics, particularly blood pressure and fasting glucose, is independently associated with a significantly increased risk of ASCVD events in a large, diverse real-world population.
Rana et al. (2020) conducted a cohort in Atherosclerotic cardiovascular disease (ASCVD) risk (n=991,698). Poor cardiovascular health metrics (e.g., blood pressure, fasting glucose) vs. Ideal cardiovascular health metrics was evaluated on Atherosclerotic cardiovascular disease (ASCVD) events (composite of non-fatal MI, fatal CHD, and fatal and non-fatal stroke). Compared with ideal categories, poor categories of blood pressure and fasting glucose were associated with the highest (approximately two-fold) increased risk for atherosclerotic cardiovascular disease events.
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