Key result
Hemophagocytic lymphohistiocytosis was associated with the development of ampulla (takotsubo-shaped) cardiomyopathy in two patients, suggesting a potential role for hypercytokinemia.
Case Report (n=2)
This report suggests that hypercytokinemia associated with hemophagocytic lymphohistiocytosis may play a role in the development of takotsubo cardiomyopathy.
Answers are grounded in this paper and cite their sources.
Association in two HLH cases should not change practice; leaves open hypercytokinemia as takotsubo trigger for validation.
There have been many reports of patients with ampulla cardiomyopathy described as takotsubo-shaped cardiomyopathy in the cardiovascular field. This unique cardiomyopathy is characterized by transient apical ballooning and hypokinesis of the left ventricle. We describe 2 cases of ampulla cardiomyopathy associated with hemophagocytic lymphohistiocytosis (HLH). In both of the patients, ventricular dysfunction suddenly occurred during the active phase of HLH. In each case, the findings on ECG, echocardiogram and left ventriculogram were compatible with ampulla cardiomyopathy. To our knowledge, this communication is the first to report cases of ampulla cardiomyopathy associated with HLH. Our cases suggest that HLH hypercytokinemia may have a role in causing ampulla cardiomyopathy.
No takes yet. Share an insight, caveat, or question.
Takeoka et al. (2007) conducted a case report in Ampulla (Takotsubo-Shaped) Cardiomyopathy associated with Hemophagocytic Lymphohistiocytosis (n=2). Hemophagocytic lymphohistiocytosis (HLH) was evaluated on Development of ampulla cardiomyopathy. Hemophagocytic lymphohistiocytosis was associated with the development of ampulla (takotsubo-shaped) cardiomyopathy in two patients, suggesting a potential role for hypercytokinemia.
Synapse has enriched 10 related papers. Consider them for comparative context: