Key result
Ten weeks of endurance training significantly decreased cardiac protein levels of NF-kB (p<0.001) and gene expression of Atrogin-1 (p<0.001) and MuRF-1 (p=0.003) in female mice with breast cancer.
Why the study?
Cardiac atrophy is a key complication of cancer, and the study investigated whether 10 weeks of endurance training affects cardiac NF-kB protein levels and Atrogin-1 and MuRF-1 gene expression.
Does 10 weeks of endurance training reduce cardiac atrophy markers (NF-kB, Atrogin-1, MuRF-1) in female mice with breast cancer?
Does 10 weeks of endurance training reduce cardiac atrophy markers (NF-kB, Atrogin-1, MuRF-1) in female mice with breast cancer?
p-value: p=<0.001
Endurance training may mitigate cancer-induced cardiac atrophy by downregulating the NF-kB/Atrogin-1/MuRF-1 inflammatory and proteolytic axis.
Background: Cardiac atrophy is the most important complications resulted by cancer Given the role of exercise in protecting against cancer complications, the aim of the present study was to determine the effect of 10 weeks of endurance training on protein levels of NF-kB and gene expression of Atrogin-1 and MuRF-1 in cardiac myocyte of female Balb/C mic with breast cancer. Methods: The present study was an experimental study. Twelve female BALB/c mice after inducing breast cancer were randomly divided into two groups (n=6) including endurance training group (E) and the control group (C). E group performed 65 min at a constant running speed corresponding to 60% vVo2max at 15% inclination, ten weeks (five days a week). The Left ventricular of animals was extracted 24h following the last training session. Protein levels of NF-kB and gene expression of Atrogin-1 and MuRF-1 were determined by, respectively, western blot and qReal-time PCR. Statistic data values also were measured by independent samples t-test at the 0.05 levels of significance. Results: The results of the present study showed a significant decreased in cardiac protein levels of NF-kB (p<0.001) and cardiac gene expression of Atrogin-1 (p<0.001) and MuRF-1 (p=0.003) in comparison with control group. Endurance training group had significantly greater heart weights compared to control group (p<0.001). Conclusion: it seems that 10 weeks of endurance training possibly affect mechanisms involved in cancer-induced cardiac atrophy such as NF-kB/Atrogin-1/MuRF-1 axis results in decreasing cardiac atrophy in mice with breast cancer.
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Shenas et al. (2021) studied Breast cancer and cancer-induced cardiac atrophy (n=12). Endurance training vs. Control (no training) was evaluated on Cardiac protein levels of NF-kB and gene expression of Atrogin-1 and MuRF-1 (p=<0.001). Ten weeks of endurance training significantly decreased cardiac protein levels of NF-kB (p<0.001) and gene expression of Atrogin-1 (p<0.001) and MuRF-1 (p=0.003) in female mice with breast cancer.
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