Animal study observes retinal ganglion cell alterations following carbamazepine exposure in adult rats, highlighting potential ocular side effects of antiepileptic therapy.
BackgroundEpilepsy is characterized by recurrent, unprovoked seizures and is a major global chronic neurological public health concern. ObjectiveTo evaluate retinal histological alterations, focusing on retinal ganglion cell count and apoptosis, following carbamazepine (CBZ) administration in adult albino Wistar rats.It is an antiepileptic drug mainly used for focal (partial) seizures, where it suppresses excessive neuronal firing by blocking voltage-gated Na⁺ channels.
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Shakoor et al. (2026) studied this question.
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