What does this research mean for the field?

PCHP-1 A, a polysaccharide from Polygonatum cyrtonema Hua, alleviates acetaminophen-induced acute liver injury in vivo by reducing oxidative stress and inflammation through the modulation of the Keap1/Nrf2 and NF-κB pathways. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

Investigate the protective efficacy and mechanistic pathways of PCHP-1 A, a polysaccharide extracted from Polygonatum cyrtonema Hua, against acetaminophen-induced acute liver injury in an in vivo model.

September 5, 2026Scientific ReportsOpen Access

PCHP‑1 A from Polygonatum cyrtonema Hua alleviates APAP‑induced acute liver injury via Nrf2/Keap1 and NF‑κB pathways

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Authors

LXLunbin XiaWest Anhui University DQDeliang QiaoWest Anhui University SBShaoshuai BiWest Anhui University

Discussion

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Implication

Animal study demonstrates that Polygonatum cyrtonema polysaccharide reduces acetaminophen-induced liver damage in mice, suggesting therapeutic potential for acute hepatic injury.

Key Points

Investigate the protective efficacy and mechanistic pathways of PCHP-1 A, a polysaccharide extracted from Polygonatum cyrtonema Hua, against acetaminophen-induced acute liver injury in an in vivo model.
Established an acute liver injury model in mice via intraperitoneal acetaminophen injection.
Assessed hepatic histopathology, serum biochemical markers (AST, ALT, LDH, ALP, TBIL), apoptosis, iron levels, and inflammatory cytokines following PCHP-1 A pretreatment.
Measured oxidative stress biomarkers and conducted molecular docking simulations to evaluate regulatory effects on the Nrf2/Keap1 and NF-κB pathways.
PCHP-1 A pretreatment significantly lowered serum AST, ALT, LDH, ALP, and TBIL levels while reducing hepatic iron accumulation and hepatocyte apoptosis.
Pretreatment suppressed proinflammatory cytokines (TNF-α, IL-1β, IL-6), decreased ROS and MDA levels, limited lipid accumulation, and increased GSH and SOD enzyme activities.
Molecular docking and mechanistic analyses confirmed that hepatoprotection occurs through activation of the Keap1/Nrf2 pathway and suppression of the NF-κB pathway.

Cite This Study

Xia et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3a66b95aff0620eadf5 https://doi.org/10.1038/s41598-026-70075-7

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Implication

Animal study demonstrates that Polygonatum cyrtonema polysaccharide reduces acetaminophen-induced liver damage in mice, suggesting therapeutic potential for acute hepatic injury.

PCHP‑1 A from Polygonatum cyrtonema Hua alleviates APAP‑induced acute liver injury via Nrf2/Keap1 and NF‑κB pathways

Discussion

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Implication

Key Points

Cite This Study

PCHP‑1 A from Polygonatum cyrtonema Hua alleviates APAP‑induced acute liver injury via Nrf2/Keap1 and NF‑κB pathways

Discussion

Member takes

Implication

Key Points

Cite This Study

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