What does this research mean for the field?

Acupuncture alleviates poststroke cognitive impairment by upregulating miR-18a-5p, which subsequently modulates HIF-1α expression and reduces inflammatory cytokine concentrations. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate whether acupuncture improves poststroke cognitive impairment and to determine whether this therapeutic effect operates through the regulation of miR-18a-5p and HIF-1α.

September 5, 2026Acupuncture & Electro-Therapeutics Research

Acupuncture Improves Poststroke Cognitive Impairment by Regulating the miR-18a-5p

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Authors

TLTianshi Li LWLi Wan HCHongyan Chen

Discussion

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Overview

Translational study demonstrates acupuncture improves cognitive function in poststroke cognitive impairment by upregulating miR-18a-5p, suggesting a promising molecular therapeutic target.

Key Points

To investigate whether acupuncture improves poststroke cognitive impairment and to determine whether this therapeutic effect operates through the regulation of miR-18a-5p and HIF-1α.
Assessed cognitive performance and activities of daily living in 107 patients with poststroke cognitive impairment and 102 healthy controls using the MMSE, Revised Hasegawa's Dementia Scale, and ADL scales.
Established middle cerebral artery occlusion in male Sprague–Dawley rats to evaluate cognitive deficits through the Morris water maze and novel object recognition tests following acupuncture or miR-18a-5p overexpression.
Investigated the direct targeting between miR-18a-5p and HIF-1α using dual-luciferase reporter and RNA immunoprecipitation assays, alongside ELISA quantification of inflammatory cytokines.
Serum miR-18a-5p levels were significantly lower in stroke patients than in healthy controls, but acupuncture increased its expression, which positively correlated with higher cognitive scores and daily living capacity.
Acupuncture and miR-18a-5p overexpression both lowered Zea-Longa neurological scores and ameliorated memory and recognition deficits in poststroke rats.
Acupuncture reversed the poststroke downregulation of hippocampal miR-18a-5p while concurrently reducing HIF-1α expression and inflammatory cytokine concentrations.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb108 https://doi.org/10.1177/03601293261479861

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September 5, 2026Acupuncture & Electro-Therapeutics Research

Acupuncture Improves Poststroke Cognitive Impairment by Regulating the miR-18a-5p

View Full Paper

Ask AI

Bookmark

Authors

TLTianshi Li LWLi Wan HCHongyan Chen

Discussion

Member takes

Overview

Translational study demonstrates acupuncture improves cognitive function in poststroke cognitive impairment by upregulating miR-18a-5p, suggesting a promising molecular therapeutic target.

Key Points

To investigate whether acupuncture improves poststroke cognitive impairment and to determine whether this therapeutic effect operates through the regulation of miR-18a-5p and HIF-1α.
Assessed cognitive performance and activities of daily living in 107 patients with poststroke cognitive impairment and 102 healthy controls using the MMSE, Revised Hasegawa's Dementia Scale, and ADL scales.
Established middle cerebral artery occlusion in male Sprague–Dawley rats to evaluate cognitive deficits through the Morris water maze and novel object recognition tests following acupuncture or miR-18a-5p overexpression.
Investigated the direct targeting between miR-18a-5p and HIF-1α using dual-luciferase reporter and RNA immunoprecipitation assays, alongside ELISA quantification of inflammatory cytokines.
Serum miR-18a-5p levels were significantly lower in stroke patients than in healthy controls, but acupuncture increased its expression, which positively correlated with higher cognitive scores and daily living capacity.
Acupuncture and miR-18a-5p overexpression both lowered Zea-Longa neurological scores and ameliorated memory and recognition deficits in poststroke rats.
Acupuncture reversed the poststroke downregulation of hippocampal miR-18a-5p while concurrently reducing HIF-1α expression and inflammatory cytokine concentrations.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd3e16b95aff0620eb108 https://doi.org/10.1177/03601293261479861

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