Chemical synthesis study demonstrates photocatalytic defluorinative coupling of alkynes with trifluoromethyl alkenes using water, suggesting scalable access to gem-difluoroalkenes.
The reductive coupling of alkynes and alkenes has emerged as a straightforward protocol for C–C bond formation from readily available feedstocks. Herein, we report a phosphine-mediated photocatalytic defluorinative reductive coupling of alkynes and trifluoromethyl alkenes with water as the hydrogen source, delivering a range of valuable gem-difluoroalkenes with excellent chemoselectivity under mild conditions. This strategy is gram-scale and can be applied for several pharmaceutical and natural product derivatives. Control experiments and spectroscopic analyses were conducted to probe the underpinning mechanism.
No takes yet. Share an insight, caveat, or question.
Ding et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: