Single-cell RNA editing identifies aggressive and favorable cellular states in chronic myelomonocytic leukemia

Nisansala Wickramasinghe; Doan Bui; Surendra Neupane; Meghan C. Ferrall‐Fairbanks; Michael Deininger; Eric Padron; Tongjun Gu

doi:10.3324/haematol.2026.301007

September 3, 2026HaematologicaOpen Access

Single-cell RNA editing identifies aggressive and favorable cellular states in chronic myelomonocytic leukemia

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Key Points

Characterize single-cell RNA editing heterogeneity to identify aggressive and favorable cellular states in chronic myelomonocytic leukemia.
Profiled RNA editing events at single-cell resolution across leukemic cell populations in chronic myelomonocytic leukemia.
Mapped epitranscriptomic alterations to distinct clonal lineages and cell differentiation trajectories.
Identified distinct epitranscriptomic signatures that distinguish highly aggressive leukemic subsets from indolent or favorable cell states.
Demonstrated that RNA editing variations correlate with phenotypic diversity and leukemic cell hierarchy.

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Implication

Molecular profiling reveals aggressive and favorable cell states in chronic myelomonocytic leukemia, indicating RNA editing as a biomarker for disease prognosis.

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Cite This Study

Wickramasinghe et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb4ad https://doi.org/10.3324/haematol.2026.301007

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Single-cell RNA editing identifies aggressive and favorable cellular states in chronic myelomonocytic leukemia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Single-cell RNA editing identifies aggressive and favorable cellular states in chronic myelomonocytic leukemia

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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