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December 8, 2025Blood

Beyond mutations: RNA editing deaminase activation as a dynamic marker to track stem cell fitness and MPN progression

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Authors

IWInge van der WerfKWKendale Wirtjes

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Overview

This work demonstrates deaminase expression may predict disease progression in myeloproliferative neoplasms, suggesting improved diagnostic strategies involving stem cells and biomarkers.

Key Points

  • The aim is to investigate the role of RNA editing deaminases as biomarkers for monitoring myeloproliferative neoplasm progression.
  • Conducted longitudinal analyses using next-generation sequencing for 129 MPN patients.
  • Measured expression levels of ADAR1 and APOBEC3C in hematopoietic stem and progenitor cells.
  • Evaluated changes in different molecular markers during patient treatment.
  • Collected multiple sequential time points for patients treated with Inrebic.
  • Identified increased expression of ADAR1 and APOBEC3C linked to high-risk myelofibrosis.
  • Noted stable variant allele frequency, but rising lactate dehydrogenase levels during treatment.
  • Found dynamic expression changes of key markers in patients progressing to acute myeloid leukemia.

Cite This Study

Werf et al. (2025) studied this question.

synapsesocial.com/papers/69362f7f4fa91c937236e5adhttps://doi.org/10.1182/blood-2025-5543
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Abstract 3752: RNA editing deaminase activation as a dynamic marker to track hematopoietic stem cell fitness and leukemia evolution2026
  2. 2Abstract 263: RNA Editing ADAR1 Deaminase Activation Responsive (READAR) platforms for dynamic detection of clonal myeloproliferative neoplasm stem cell fitness2024
  3. 3Peripheral blood-based single-cell and genomic profiling of hematopoietic stem and progenitor cells enables accurate diagnosis and risk stratification in myeloproliferative neoplasms2025
  4. 4Digital PCR-based dynamic monitoring of JAK2V617F burden: A decade-long study unravels its prognostic value in MPN treatment response2025
  5. 5Abstract 1485: Hallmarks of APOBEC3 mutagenesis in normal, pre-leukemic, and myeloproliferative neoplasm cell populations2024