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December 8, 2025BloodOpen Access

Digital PCR-based dynamic monitoring of JAK2V617F burden: A decade-long study unravels its prognostic value in MPN treatment response

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Authors

HCHao CaiLJLi JMDMinghui Duan

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Overview

Longitudinal monitoring shows higher molecular response in polycythemia vera patients receiving interferon-alpha, suggesting valuable prognostic insights for therapeutic assessment.

Key Points

  • Evaluate dynamic changes in JAK2V617F and their prognostic value for treatment response in myeloproliferative neoplasms.
  • Cohort of 445 JAK2V617F-positive MPN patients
  • Used digital PCR for variant allele frequency assessment
  • Examined correlations with treatment regimens and response rates
  • Digital PCR provides precise quantification of JAK2V617F variant allele frequency
  • Polycythemia vera patients showed 71% response to interferon-alpha therapy
  • Leukemic transformation associated with adverse treatment outcomes

Cite This Study

Cai et al. (2025) studied this question.

synapsesocial.com/papers/69362f694fa91c937236df79https://doi.org/10.1182/blood-2025-5597
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Evaluation of Quantitative Real-Time PCR and a Laboratory-Developed Chip-Based Real-Time Digital PCR for JAK2 V617F Allele Burden in Myeloproliferative Neoplasms2026
  2. 2Clinical and Molecular Challenges in Diagnosing Myeloproliferative Neoplasms with Low JAK2V617F Allelic Burden: A Single-Center Perspective and Literature Overview2026
  3. 3High-frequency monitoring of clonal dynamics in MPN using saliva and peripheral blood during interferon therapy2025 · 1 citations
  4. 4Contribution of molecular characterization to the diagnosis of MPN in patients with low JAK2V617F variant allelic fraction in a real-world cohort2025 · 5 citations
  5. 5JAK2 V617F Clonal Dynamics from Clonal Hematopoiesis to Myeloproliferative Neoplasms: A Systems Biology Review of Digital PCR-Based Molecular Monitoring2026