Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2026International Journal of Translational MedicineOpen Access

Clinical and Molecular Challenges in Diagnosing Myeloproliferative Neoplasms with Low JAK2V617F Allelic Burden: A Single-Center Perspective and Literature Overview

View Full Paper
Ask AI
Bookmark
Share

Authors

EMErika MorsiaMarche Polytechnic UniversityDLDorela LameMarche Polytechnic UniversityMPMichelangelo PianelliMarche Polytechnic University

Discussion

Loading...

Member takes

Implication

Retrospective study evaluates thrombotic risk and hematologic evolution in patients with low JAK2 V617F burden, indicating clinical significance.

Key Points

  • This research evaluates the clinical relevance and thrombotic risk of low JAK2 V617F mutations.
  • Conducted a retrospective analysis of adult patients tested for JAK2 V617F from January 2016 to December 2023.
  • Included patients with variant allele frequency <2% and without MPN diagnostic criteria.
  • Analyzed clinical characteristics, laboratory parameters, and thrombotic events.
  • 55 out of 2,372 tested subjects had low-level JAK2 V617F mutations (median VAF 0.35%).
  • 21.8% of patients progressed to overt MPN after a median follow-up of 31.7 months.
  • Thrombotic events occurred in 30.9% of patients and were linked to higher VAF values.

Cite This Study

Morsia et al. (2026) studied this question.

synapsesocial.com/papers/69ccb5f716edfba7beb87bcbhttps://doi.org/10.3390/ijtm6020013
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Superior detection of low-allele burden Janus kinase 2 V617F mutation and monitoring clonal evolution in myeloproliferative neoplasms using chip-based digital PCR2024 · 5 citations
  2. 2The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia2016 · 10,405 citations
  3. 3The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms2022 · 4,237 citations
  4. 4Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes2014 · 4,937 citations