What question did this study set out to answer?

This study aims to explore the relationship between JAK2 V617F mutations and thrombotic events in BCR-ABL1-negative myeloproliferative neoplasms (MPNs).

April 13, 2026Leukemia Research ReportsOpen Access

JAK2 V617F Mutations and Thrombosis in BCR-ABL1 Negative Myeloproliferative Neoplasms: Clinical Profile and Hematologic Insights

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Authors

ALAnna Mira LubisUniversity of Indonesia MBMuhammad Orri Baskoro GAGabriella AnindyahUniversity of Indonesia

Discussion

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Implication

Retrospective analysis reveals associations between JAK2 V617F mutations, hematologic profiles, and thrombosis in MPN patients, indicating clinical significance.

Key Points

This study aims to explore the relationship between JAK2 V617F mutations and thrombotic events in BCR-ABL1-negative myeloproliferative neoplasms (MPNs).
Retrospective analysis of 198 patients with BCR-ABL1-negative MPNs
Assessment of JAK2 V617F mutation status and hematologic parameters
Evaluation of clinical features and thrombotic events
Statistical analysis to determine associations among variables
Patients under 40 years old frequently had JAK2 V617F-negative MPN (p<0.05)
In patients with polycythemia vera (PV), cardiovascular comorbidities were linked to a 4.5-fold increased risk of thrombosis (OR 4.59; CI 1.57-13.43; p=0.005)
Mutated-JAK2 V617F MPNs exhibited lower platelet counts and higher white blood cell (WBC) counts
Thrombosis was associated with higher hemoglobin and hematocrit levels (p<0.01)
No independent association between JAK2 V617F mutation and thrombotic events was found across all MPN subtypes

Cite This Study

Lubis et al. (2026) studied this question.

synapsesocial.com/papers/69dc88303afacbeac03ea234 https://doi.org/10.1016/j.lrr.2026.100588

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Implication

Retrospective analysis reveals associations between JAK2 V617F mutations, hematologic profiles, and thrombosis in MPN patients, indicating clinical significance.

JAK2 V617F Mutations and Thrombosis in BCR-ABL1 Negative Myeloproliferative Neoplasms: Clinical Profile and Hematologic Insights

Discussion

Member takes

Implication

Key Points

Cite This Study

JAK2 V617F Mutations and Thrombosis in BCR-ABL1 Negative Myeloproliferative Neoplasms: Clinical Profile and Hematologic Insights

Discussion

Member takes

Implication

Key Points

Cite This Study

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