What does this research mean for the field?

Early LMWH-based anticoagulation is safe and does not cause inpatient intracranial hemorrhagic deterioration in selected patients with traumatic cerebral venous sinus thrombosis, although its effect on functional outcomes remains uncertain. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the clinical course, radiological features, and safety of anticoagulation strategies in patients with traumatic cerebral venous sinus thrombosis following traumatic brain injury.

September 5, 2026Acta NeurochirurgicaOpen Access

Clinical course of traumatic cerebral venous sinus thrombosis: Insights from a UK major trauma centre

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Authors

SMSheikh MominQueen Elizabeth Hospital Birmingham FAFaheem AnwarTianjin University GSGeorgina ShallardUniversity of Birmingham

Discussion

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Overview

Retrospective cohort study reveals early anticoagulation causes no inpatient intracranial bleeding in traumatic venous sinus thrombosis, indicating initial safety in selected patients.

Key Points

To evaluate the clinical course, radiological features, and safety of anticoagulation strategies in patients with traumatic cerebral venous sinus thrombosis following traumatic brain injury.
Conducted a retrospective cohort study of patients aged >16 years with radiologically confirmed traumatic venous sinus thrombosis who survived ≥48 hours following traumatic brain injury between January 2020 and December 2023 at a UK Major Trauma Centre (N=56).
Categorized inpatient anticoagulation into three regimens for comparative analysis: no low-molecular-weight heparin (LMWH), prophylactic LMWH only, and any therapeutic-dose anticoagulation exposure.
Venous sinus thrombosis was diagnosed in 56 of 1,411 traumatic brain injury admissions (4.0%), with skull fractures present in 53 of 56 patients (95.0%) and directly overlying the thrombosed sinus in 50 of 56 (89.3%).
Anticoagulation was administered to 50 of 56 patients (starting ≤48 hours in 74% and ≤5 days in 90%); follow-up CT venography in 47 patients demonstrated full recanalisation in 10, partial recanalisation in 22, and no recanalisation in 15.
No inpatient anticoagulation-related intracranial haemorrhagic progression or neurological deterioration occurred, and 3-month Glasgow Outcome Scale-Extended (GOS-E) scores did not differ significantly between anticoagulation regimens.

Cite This Study

Momin et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb542 https://doi.org/10.1007/s00701-026-07000-4

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September 5, 2026Acta NeurochirurgicaOpen Access

Clinical course of traumatic cerebral venous sinus thrombosis: Insights from a UK major trauma centre

View Full Paper

Ask AI

Bookmark

Authors

SMSheikh MominQueen Elizabeth Hospital Birmingham FAFaheem AnwarTianjin University GSGeorgina ShallardUniversity of Birmingham

Discussion

Member takes

Overview

Retrospective cohort study reveals early anticoagulation causes no inpatient intracranial bleeding in traumatic venous sinus thrombosis, indicating initial safety in selected patients.

Key Points

To evaluate the clinical course, radiological features, and safety of anticoagulation strategies in patients with traumatic cerebral venous sinus thrombosis following traumatic brain injury.
Conducted a retrospective cohort study of patients aged >16 years with radiologically confirmed traumatic venous sinus thrombosis who survived ≥48 hours following traumatic brain injury between January 2020 and December 2023 at a UK Major Trauma Centre (N=56).
Categorized inpatient anticoagulation into three regimens for comparative analysis: no low-molecular-weight heparin (LMWH), prophylactic LMWH only, and any therapeutic-dose anticoagulation exposure.
Venous sinus thrombosis was diagnosed in 56 of 1,411 traumatic brain injury admissions (4.0%), with skull fractures present in 53 of 56 patients (95.0%) and directly overlying the thrombosed sinus in 50 of 56 (89.3%).
Anticoagulation was administered to 50 of 56 patients (starting ≤48 hours in 74% and ≤5 days in 90%); follow-up CT venography in 47 patients demonstrated full recanalisation in 10, partial recanalisation in 22, and no recanalisation in 15.
No inpatient anticoagulation-related intracranial haemorrhagic progression or neurological deterioration occurred, and 3-month Glasgow Outcome Scale-Extended (GOS-E) scores did not differ significantly between anticoagulation regimens.

Cite This Study

Momin et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4046b95aff0620eb542 https://doi.org/10.1007/s00701-026-07000-4

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