Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Ibrahim Aldoss; Arthur Li; Diana Knobler; Vaibhav Agrawal; Hoda Pourhassan; Paul Koller; Tamer Othman; Monzr M. Al Malki; Amandeep Salhotra; Karamjeet Sandhu; Haris Ali; Ahmed Aribi; Amanda Blackmon; Brian Ball; Idoroenyi Amanam; Salman Otoukesh; Rick Lin; Julio C. Alvarenga Thiebaud; Sunmin Park; Samer Khaled; Jose Tinajero; Dat Ngo; Zhaohui Gu; Lindsey Murphy; Yazeed Samara; Michelle Afkhami; Andrew Artz; Pamela Becker; Ryotaro Nakamura; Anthony Stein; Stephen Forman; Guido Marcucci; Vinod Pullarkat

doi:10.3324/haematol.2026.301486

Key Points

To evaluate the clinical characteristics and therapeutic outcomes of young adults with Philadelphia-like acute lymphoblastic leukemia treated with pediatric-inspired regimens and targeted consolidations.
Retrospectively analyzed N=140 consecutive adult patients with Philadelphia-like acute lymphoblastic leukemia treated at a single institution (median age 33.5 years).
Characterized genomic features including CRLF2 rearrangements (85%), IKZF1plus deletions (26%), and JAK mutations (37%).
Evaluated outcomes according to treatment approach, with 75% of patients receiving pediatric-inspired regimens.
Pediatric-inspired regimens were associated with significantly higher complete remission rates compared to alternative regimens (p=0.034).
Patients receiving pediatric-inspired regimens experienced a reduced risk of disease relapse.

No abstract yet

We only have this paper's title and publication details.

Read it at the source

Ask about this paper

Answers are grounded in this paper and cite their sources.

Implication

Retrospective study reveals improved remission and lower relapse with pediatric-inspired therapy in Philadelphia-like acute lymphoblastic leukemia, indicating superior treatment strategies.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Aldoss et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4126b95aff0620eb5f7 https://doi.org/10.3324/haematol.2026.301486

View Full Paper

Ask AI

Bookmark

Share

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Pediatric-inspired therapy and blinatumomab consolidation improve outcomes in young adults with Philadelphia-like acute lymphoblastic leukemia

Key Points

No abstract yet

Ask about this paper

Implication

Discussion

Cite This Study

Keep reading

Keep reading