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September 5, 2026Journal of Peptide Science

Novel Peptide–Triazole Conjugates: Strategic Synthesis, Antimicrobial Properties, and Molecular Docking Study

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Authors

JBJigar BhavsarSTSunil TivariSPSwati Swornaprava Pati

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Overview

In vitro study reveals novel peptide–triazole conjugates effectively inhibit multidrug-resistant bacterial and fungal pathogens, suggesting potential utility against drug-resistant infections.

Key Points

  • Design and synthesize novel octapeptide-triazole conjugates containing non-proteinogenic amino acids and evaluate their antimicrobial activity and molecular docking profiles against multidrug-resistant pathogens.
  • Synthesized octapeptide-triazole conjugates incorporating non-proteinogenic amino acids (2-aminoisobutyric acid and 2-naphthylalanine) via solid-phase peptide synthesis (SPPS).
  • Evaluated in vitro antimicrobial activity against bacterial (E. coli, P. aeruginosa) and fungal (C. albicans) strains by determining minimum inhibitory concentration (MIC) values, supplemented by molecular docking analysis.
  • Compound 7e showed antibacterial activity against E. coli with a minimum inhibitory concentration (MIC) of 12 μg/mL.
  • Compound 7a demonstrated antibacterial activity against P. aeruginosa with an MIC of 12 μg/mL and antifungal activity against C. albicans with an MIC of 25 μg/mL.

Cite This Study

Bhavsar et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4126b95aff0620eb6a8https://doi.org/10.1002/psc.70122
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