Narrative review reveals determinants of cat and dog allergies in sensitized individuals, highlighting precision management through molecular diagnosis and clinical concordance.
Key Points
Synthesize molecular allergen biology, environmental transmission dynamics, and diagnostic tools to establish a precision-management framework for cat and dog allergies.
Conducted a narrative review examining molecular allergen structures, environmental carriers, and IgE-mediated immune mechanisms in mammalian pet allergy.
Synthesized current clinical evidence on component-resolved diagnosis, environmental control interventions, allergen immunotherapy, and pharmacotherapies.
Identified that clinical pet allergy depends on exposure-response concordance and host factors rather than mere environmental presence of proteins like Fel d 1 and Can f 1.
Showed that component-resolved diagnosis effectively distinguishes species-specific sensitization from cross-reactivity, guiding tailored immunotherapy while standard pharmacotherapy maintains primary symptom control.