Expanding the Scope of Indium in Frustrated Lewis Pair Chemistry

Q: What does this research mean for the field?

The "soft" pyridine-stabilized indium frustrated Lewis pair tBu2In(py)CH2PtBu2 exhibits three distinct reactivity modes depending on the substrate: typical FLP activation, "soft" site-preferential coordination, and unexpected "masked" In/C-FLP reactivity. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

Daniel N. Heuer; Jan‐Hendrik Lamm; Beate Neumann; Andreas Mix; Yury V. Vishnevskiy; Norbert W. Mitzel

doi:10.1002/chem.71415

September 3, 2026Chemistry - A European JournalOpen Access

Expanding the Scope of Indium in Frustrated Lewis Pair Chemistry

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Key Points

To evaluate the reactivity, coordination preferences, and activation pathways of the pyridine-stabilized indium-based frustrated Lewis pair tBu2In(py)CH2PtBu2 across various organic and inorganic substrates.
Reacted tBu2In(py)CH2PtBu2 with SO2, PhNCO, PhNSO, azobenzene, pyridazine, 1,2,4,5-tetrazine, tosylaziridine, and hydrazine under controlled conditions.
Characterized reaction outcomes using multinuclear NMR spectroscopy and single-crystal X-ray crystallography.
Performed quantum-chemical calculations to evaluate the reaction thermodynamics and product selectivity.
Observed standard FLP addition and ring-opening pathways with azobenzene and tosylaziridine, alongside site-selective 'soft' coordination to PhNCO and PhNSO.
Identified masked indium/carbon FLP behavior with sulfur dioxide to yield an insertion dimer and with hydrazine to form a four-membered hydrazide ring with methylene bridge loss.

Implication

Chemical reactivity study demonstrates diverse activation pathways of a pyridine-stabilized indium frustrated Lewis pair across multiple small molecules, indicating expanded utility for heavy...

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Cite This Study

Heuer et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4216b95aff0620eb8b2 https://doi.org/10.1002/chem.71415

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Expanding the Scope of Indium in Frustrated Lewis Pair Chemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

Expanding the Scope of Indium in Frustrated Lewis Pair Chemistry

Key Points

Implication

Abstract

Discussion

Cite This Study

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