Post-Infectious Sequelae Following a Shiga Toxin-Producing Escherichia coli Outbreak among U.S. Marine Corps Recruits

Q: What does this research mean for the field?

Shiga toxin-producing Escherichia coli (STEC) infection, including cases with hemolytic uremic syndrome, does not significantly increase the long-term risk of hypertension, renal dysfunction, or irritable bowel syndrome over a 3.7-year period. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Michelle Kautz; Derek Larson; Hsing-Chuan Hseih; Ryan C. Maves; Tahaniyat Lalani

doi:10.1093/ofid/ofag569

September 3, 2026Open Forum Infectious DiseasesOpen Access

Post-Infectious Sequelae Following a Shiga Toxin-Producing Escherichia coli Outbreak among U.S. Marine Corps Recruits

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Key Points

To evaluate the risk of long-term post-infectious sequelae following an outbreak of Shiga toxin–producing Escherichia coli (STEC).
Retrospectively analyzed 239 STEC cases and 686 controls among Marine Corps recruits.
Assessed long-term clinical sequelae over a 3.7-year follow-up period, focusing on hypertension, renal dysfunction, and irritable bowel syndrome.
Incidence rates of hypertension, renal dysfunction, and irritable bowel syndrome were rare and not significantly increased in STEC cases compared to controls over 3.7 years.
Outcomes remained rare without significant increases even among patients who developed hemolytic uremic syndrome during the acute phase.

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Implication

Retrospective cohort study finds no significant increase in post-infectious sequelae after Shiga toxin–producing E. coli infection in military recruits, indicating favorable long-term recovery.

Abstract

We retrospectively compared 239 Shiga toxin–producing Escherichia coli (STEC) cases and 686 controls from an outbreak among Marine Corps recruits to assess post-infectious sequelae. Over 3.7 years, hypertension, renal dysfunction, and irritable bowel syndrome were rare and not significantly increased among cases, including those with hemolytic uremic syndrome.

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Kautz et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4346b95aff0620ebb18 https://doi.org/10.1093/ofid/ofag569

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Post-Infectious Sequelae Following a Shiga Toxin-Producing Escherichia coli Outbreak among U.S. Marine Corps Recruits

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Post-Infectious Sequelae Following a Shiga Toxin-Producing Escherichia coli Outbreak among U.S. Marine Corps Recruits

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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