Bone marrow biopsy characteristics at nadir after intensive induction therapy do not predict outcomes in adult acute myeloid leukemia patients: an analysis of ECOG-ACRIN clinical trials

Douglas Tremblay; Li Chen; Zhuoxin Sun; Chezi Ganzel; Hugo Fernandez; James Foran; Daniel A. Arber; Hillard Lazarus; Yanming Zhang; Elisabeth Paietta; John M. Bennett; Jacob Rowe; Mark Litzow; Martin Tallman; E. Atallah; Selina Luger

doi:10.3324/haematol.2026.301202

September 3, 2026HaematologicaOpen Access

Bone marrow biopsy characteristics at nadir after intensive induction therapy do not predict outcomes in adult acute myeloid leukemia patients: an analysis of ECOG-ACRIN clinical trials

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Key Points

To determine whether morphological and cellular features of bone marrow biopsies obtained at nadir after intensive induction chemotherapy predict clinical outcomes in adult patients with acute myeloid leukemia.
Evaluated bone marrow biopsy findings at nadir among adult patients with acute myeloid leukemia participating in ECOG-ACRIN clinical trials.
Analyzed associations between post-induction nadir biopsy characteristics and subsequent clinical outcomes including remission and survival.
Bone marrow biopsy characteristics assessed during the nadir phase demonstrated no statistically significant predictive value for patient outcomes.
Early nadir marrow findings failed to reliably stratify long-term therapeutic responses or overall prognosis following intensive induction therapy.

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Implication

Clinical trial analysis reveals nadir bone marrow biopsy characteristics do not predict outcomes in acute myeloid leukemia, suggesting limited clinical utility for routine nadir assessments.

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Tremblay et al. (2026) studied this question.

synapsesocial.com/papers/6a9bd4436b95aff0620ebc78 https://doi.org/10.3324/haematol.2026.301202

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Bone marrow biopsy characteristics at nadir after intensive induction therapy do not predict outcomes in adult acute myeloid leukemia patients: an analysis of ECOG-ACRIN clinical trials

Key Points

No abstract yet

Implication

Discussion

Cite This Study

Bone marrow biopsy characteristics at nadir after intensive induction therapy do not predict outcomes in adult acute myeloid leukemia patients: an analysis of ECOG-ACRIN clinical trials

Key Points

No abstract yet

Implication

Discussion

Cite This Study

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