Cross-sectional analysis reveals distinct sedentary and active behavioral profiles in renal and colorectal cancer survivors, highlighting the need for tailored lifestyle interventions.
Key Points
To identify distinct physical activity and sedentary behaviour profiles and evaluate their demographic, clinical, and lifestyle correlates in patients with localised renal cell carcinoma (RCC) and colorectal cancer (CRC) shortly after completing treatment.
Analyzed accelerometer-measured movement data from the ReLife cohort (N=326 RCC patients, 3 months post-treatment) and the EnCoRe cohort (N=358 CRC patients, 6 weeks post-treatment).
Identified activity patterns using latent profile analyses and evaluated demographic, lifestyle, and clinical correlates using multinomial logistic regression.
Categorized patients across both cancer types into three distinct profiles: most sedentary (RCC: 28%, CRC: 16%), average (RCC: 50%, CRC: 53%), and highly active (RCC: 22%, CRC: 31%).
In the most sedentary profile, mean sedentary time reached 11.9 h/day in RCC and 13.1 h/day in CRC, with male sex (RCC: OR, 2.18; 95% CI, 1.06–4.47) and higher fatigue scores (per point: RCC OR, 0.98; 95% CI, 0.96–1.00; CRC OR, 0.98; 95% CI, 0.96–0.99) acting as key correlates.
Factors associated with the highly active profile included male sex in CRC (OR, 0.38; 95% CI, 0.20–0.71), higher education level (RCC OR, 0.31 [95% CI, 0.14–0.72]; CRC OR, 0.46 [95% CI, 0.22–0.96]), and higher BMI (per 1 kg/m²: RCC OR, 0.91 [95% CI, 0.84–0.99]; CRC OR, 0.92 [95% CI, 0.86–0.99]).