Case report demonstrates confirmed pulmonary tuberculosis in a rhesus macaque using imaging and PCR, highlighting critical zoonotic transmission risks and diagnostic strategies.
Pulmonary tuberculosis caused by the Mycobacterium tuberculosis complex (MTC) was diagnosed in a 6-year-old female rhesus macaque (Macaca mulatta) presented with a three-month history of intermittent coughing, dyspnea, weight loss, and inappetence. Hematological evaluation revealed moderate regenerative anemia and neutrophilic leukocytosis, while the thoracic radiography demonstrated a diffuse nodular interstitial pulmonary pattern consistent with tuberculosis. The diagnosis was confirmed by IS6110-targeted PCR. This case underscores the utility of combining radiographic and molecular diagnostic approaches for the early confirmation of tuberculosis in nonhuman primates and highlights its important zoonotic implications.
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Narang et al. (2026) studied this question.
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